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Rabbit Anti-βcasein
Catalog Number : HZ22424 Quantity size : 0.1ml （dilute with pH
7.4 0.01 M PBS or antibody diluent ）
Rabbit Anti-βcaseinBackground: Milk proteins are crucial for the development of all newborn
mammals and caseins constitute the major proteins in mammalian milk. β- and
κ-caseins are the only caseins present in human milk. The β-casein/κ-casein ratio is
higher in colostrum than in transitional and mature milk and is related to a better
digestibility of colostrum casein micelles by the neonate during the first days of life.
Human β-casein-encoding gene （Bca） contains a highly phosphorylated site, which is
responsible for the calcium-binding capacity of β -casein. A common set of
transcription factors are required for the expression of β-casein. Multiple binding sites
for Stat5, C/EBP β （CCAAT/enchancerbinding protein） and several half-sites for
glucocorticoid receptor （GR） are identified in the distal human enhancer of the
β-casein gene. β-casein gene transcription is regulated primarily by a composite
response element （CoRE）, which integrates signaling from the lactogenic hormones
PRL, insulin and hydrocortisone in mammary epithelial cells. NFκB functions as a
negative regulator of β-casein gene expression during pregnancy by interfering with
Stat5 tyrosine phosphorylation.
Rabbit Anti-βcaseinpecificity :
– Anti-βcasein is a rabbit polyclonal antibody unconjugated
– specific for βcasein of human, mouse, rat,pig,bovine
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 29 kDa
Rabbit Anti-βcaseinApplication :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Rabbit Anti-βcaseinStorage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The
lyophilized antibody is stable at room temperature for at least one month and for
greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M
PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for
use in human, therapeutic or diagnostic applications.